The development and maintenance of the liver tissue with the help of Kupffer cells
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Abstract
Kupffer cells are a group of star-shaped cells in hepatic sinusoids responsible for the formation of the liver and immunological-inflammatory reactions. Macrophages first begin to improve in the yolk sac and mature into kupffer cells during pregnancy. Kupffer cells are a component of the mononuclear phagocytic system, which plays a considerable role in the repair of liver damage by promoting the secretion of cytokines and chemokines involved in the hepatic and systemic response. In case of a disease situation, kupffer cells become pathologically active from the tolerogenic feature, which can lead to hepatocellular damage. Therefore, as in other components of the immune system, the continuity of proper kupffer cell activity has an important role in maintaining the vitality of the organism. A decrease in the number or loss of function of kupffer cells can lead to inflammatory conditions as a result of pathogen invasion of the liver. This brief review study, it is aimed to examine the research evaluating the functions of kupffer cells in liver development and repair.
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References
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