Overview of neurodegenerative disease

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Havva Türkben
Furkan Ayaz


Neurodegenerative diseases are connected with the degeneration of neurons, together with they may be of genetic origin or develop due to environmental factors. These diseases affect certain features of neurons and result in the inability to fully fulfill or lose some functions in the person. The leading neurodegenerative diseases are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) disease. The epidemiology and pathogenesis of these and other neurodegenerative diseases have not yet been completely explained. Within the scope of this research, neurodegenerative diseases are closely examined, the treatments applied are evaluated, and the molecular changes in the formation and course of the disease are detailed.

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Türkben , H. ., & Ayaz, F. . (2022). Overview of neurodegenerative disease . Engineering Applications, 1(2), 117–123. Retrieved from https://publish.mersin.edu.tr/index.php/enap/article/view/743


Checkoway, H., Lundin, J. I., & Kelada, S. N. (2011). Nörodejeneratif hastalıklar. IARC bilimsel yayınları, (163), 407-419.

Mayeux, R. (2003). Epidemiology of neurodegeneration. Annual review of neuroscience, 26, 81.

Poewe, W., Seppi, K., Tanner, CM, Halliday, G.M., Brundin, P., Volkmann, J., ... & Lang, A. E. (2017). Parkinson's disease. Nature studies Disease primaries, 3 (1), 1-21.

Shimohama, S., Sawada, H., Kitamura, Y., & Taniguchi, T. (2003). Disease model: Parkinson's disease. Trends in molecular medicine, 9 (8), 360-365.

Çakmur, R. (2011). Parkinson's disease and its medical treatment. Clinical Development, 23(1), 53-61.

Vázquez-Vélez, G. E., & Zoghbi, H. Y. (2021). Parkinson's disease genetics and pathophysiology. Annual Review of Neuroscience, 44, 87-108.

Agid, Y. (1991). Parkinson's disease: pathophysiology. The Lancet, 337 (8753), 1321-1324

Moore, D. J., West, A. B., Dawson, V. L., & Dawson, T. M. (2005). Molecular pathophysiology of Parkinson's disease. Annu. Rev. Neurosci., 28, 57-87.

Bergman, H., & Deuschl, G. (2002). Pathophysiology of Parkinson's disease: from clinical neurology to basic neuroscience and back. Movement disorders: official journal of the Movement Disorder Society, 17(S3), S28-S40.

Aslan, S. N., & Karahalil, B. (2019). Oksidatif stres ve Parkinson Hastaliği. Journal of Faculty of Pharmacy of Ankara University, 43(1), 94-116.

Kurman, Y. (2018). Parkinson's Disease and Associated Genes. Düzce University Journal of Science and Technology, 6(1), 231-239

Gatto, N. M., Rhodes, S. L., Manthripragada, A. D., Bronstein, J., Cockburn, M., Farrer, M., & Ritz, B. (2010). α-Synuclein gene may interact with environmental factors in increasing risk of Parkinson’s disease. Neuroepidemiology, 35(3), 191-195.

Akbayır, E., Şen, M., Ay, U., Şenyer, S., Tüzün, E., Küçükali, C. İ. (2017). Etiopathogenesis of Parkinson's Disease. Journal of Experimental Medicine, 7(13).

Noyce, A. J., Bestwick, J. P., Silveira‐Moriyama, L., Hawkes, C. H., Giovannoni, G., Lees, A. J., & Schrag, A. (2012). Meta‐analysis of early nonmotor features and risk factors for Parkinson disease. Annals of neurology, 72(6), 893-901.

Carr, L. A., & Rowell, P. P. (1990). Attenuation of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neurotoxicity by tobacco smoke. Neuropharmacology, 29(3), 311-314.

Zarei, S., Carr, K., Reiley, L., Diaz, K., Guerra, O., Altamirano, P. F., ... & Chinea, A. (2015). A comprehensive review of amyotrophic lateral sclerosis. Surgical neurology international, 6.

Sharma, R., Hicks, S., Berna, C. M., Kennard, C., Talbot, K., & Turner, M. R. (2011). Oculomotor dysfunction in amyotrophic lateral sclerosis: a comprehensive review. Archives of neurology, 68(7), 857-861.

Şener, H. Ö., Parman, Y., Şengün, İ., Koç, F., & Oflazer, P. (2009). Stem Cell Applications in Amyotrophic Lateral Sclerosis. Turkish Journal of Neurology, 15(3), 105-108.

Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: a clinical review. European journal of neurology, 27(10), 1918-1929.

Anonymous, 2022, Disease models, https://www.als.org/research/research-we-fund/scientific-focus-areas/disease-models. ALS association.

Bouwman, F. H., Frisoni, G. B., Johnson, S. C., Chen, X., Engelborghs, S., Ikeuchi, T., ... & Teunissen, C. (2022). Clinical application of CSF biomarkers for Alzheimer's disease: From rationale to ratios. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14(1), e12314.

Türkben, H., & Ayaz, F. (2022). Dendritic cells: Their functions in immunity and disease. Advanced Engineering Days (AED), 4, 16-17.