Roles and activities of myeloid-derived suppressor cells (MDSC)
Keywords:
MDSC, PMN-MDSC, M-MDSC, Tumor, CancerAbstract
The term "myeloid-derived suppressor cells" (MDSC) refers to a diverse community of primarily immature myeloid cells that are pathologically activated and have strong immunosuppressive properties. They are in charge of the immune response in a variety of pathological conditions and are intimately connected to subpar clinical results in the progression of cancer. Depending on the expression of cell surface markers, they are divided into three groups: polymorphonuclear (PMN-MDSC), monocyte (M-MDSC), and early MDSCs. PMN-MDSCs in this group share morphological and phenotype features with neutrophils, while M-MDSCs are characterized by their similarity to monocytes and high plasticity. MDSCs enter the circulation before they complete their maturation, as a result of stimulation of the bone marrow by different growth factors, chemokines, and cytokines, which are caused by inflammation, in anti-tumor immune responses. In this study, we will review the functions and activities of MDSCs.
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