Roles and activities of myeloid-derived suppressor cells (MDSC)
Keywords:MDSC, PMN-MDSC, M-MDSC, Tumor, Cancer
The term "myeloid-derived suppressor cells" (MDSC) refers to a diverse community of primarily immature myeloid cells that are pathologically activated and have strong immunosuppressive properties. They are in charge of the immune response in a variety of pathological conditions and are intimately connected to subpar clinical results in the progression of cancer. Depending on the expression of cell surface markers, they are divided into three groups: polymorphonuclear (PMN-MDSC), monocyte (M-MDSC), and early MDSCs. PMN-MDSCs in this group share morphological and phenotype features with neutrophils, while M-MDSCs are characterized by their similarity to monocytes and high plasticity. MDSCs enter the circulation before they complete their maturation, as a result of stimulation of the bone marrow by different growth factors, chemokines, and cytokines, which are caused by inflammation, in anti-tumor immune responses. In this study, we will review the functions and activities of MDSCs.
Dölen, Y. (2013). Meme kanseri modelinde myeloid kökenli hücrelerin immün kompartmanlardaki dağılımının anti-tümör yanıtlara yansıması. Doctoral dissertation, Hacettepe University
Koca, G., Seydou, S., & Yildirim, Ö. (2022). Kanser immünoterapisinde güncel yaklaşımlar ve immünoterapinin sınırlayıcı etkilerine genel bakış. Turkish Journal of Clinics and Laboratory, 13(1), 153-165.
Qu, P., Wang, L. Z., & Lin, P. C. (2016). Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment. Cancer letters, 380(1), 253-256.
Tomela, K., Pietrzak, B., Galus, Ł., Mackiewicz, J., Schmidt, M., Mackiewicz, A. A., & Kaczmarek, M. (2023). Myeloid-Derived Suppressor Cells (MDSC) in Melanoma Patients Treated with Anti-PD-1 Immunotherapy. Cells, 12(5), 789.
Veglia, F., Sanseviero, E., & Gabrilovich, D. I. (2021). Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity. Nature Reviews Immunology, 21(8), 485-498.
Dombaz, F. (2022). COVID-19 pozitif hastalarda G-MDSC benzeri alt gruplardaki fenotipik ve fonksiyonel farklılıkların araştırılması. Master's thesis, Bursa Uludağ University
Yin, Z., Li, C., Wang, J., & Xue, L. (2019). Myeloid‐derived suppressor cells: roles in the tumor microenvironment and tumor radiotherapy. International journal of cancer, 144(5), 933-946.
Li, Y., He, H., Jihu, R., Zhou, J., Zeng, R., & Yan, H. (2021). Novel characterization of myeloid-derived suppressor cells in tumor microenvironment. Frontiers in Cell and Developmental Biology, 9, 698532.
Gabrilovich, D. I. (2017). Myeloid-derived suppressor cells. Cancer immunology research, 5(1), 3-8.
Tcyganov, E., Mastio, J., Chen, E., & Gabrilovich, D. I. (2018). Plasticity of myeloid-derived suppressor cells in cancer. Current opinion in immunology, 51, 76-82.