Different types, pathogenesis and cytokine network of Psoriasis
Keywords:Psoriasis, Cytokine, Keratinocyte cells, Hyperproliferation
Psoriasis is an autoimmune and dermatological disease characterized by high differentiation of keratinocyte cells, which are found in 5% of the skin. In the pathogenesis of psoriasis, functional changes in the HLA-Cw susceptibility allele and dendritic cells, which play an important role in cytokine secretion, helper T cells and keratinocytes are involved. With the alteration of this susceptibility allele, psoriasis is categorized in 7 different phenotypes, according to the sites of involvement. The treatment of the disease is possible in different ways such as topical, systemic and phototherapy. In this review proceeding, we will focus on different types and pathogenesis of psoriasis.
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