The role of HAMLET in cancer treatment

Abstract

HAMLET (Human Alpha-lactalbumin Made Lethal to Tumor cells) is a new antitumor protein-lipid complex that largely kills cancer cells while protecting healthy cells. HAMLET is formed by the incorporation of incompletely folded alpha-lactalbumin oleic acid found in large quantities in human milk. HAMLET is thought to activate apoptosis by targeting pathways that maintain cell viability in cancer cells. Clinical studies with HAMLET have identified HAMLET as an anticancer agent that kills tumor cells. In this proceeding we will review HAMLET as anti-tumor agent.