Studies on cytokine storm

Abstract

The term cytokine storm or cytokine cascade was first used in an article published in 1993 and is still a term used for uncontrollable inflammatory responses, but it still cannot be fully explained today. Cytokine storm can occur in many diseases of the central nervous system, either infectious or non-infectious. In most of the patients, the release levels of proinflammatory cytokines such as interferons, tumor necrosis factor, interleukins and chemokines are significantly high. The molecular mechanism of the cytokine storm has not been clearly elucidated and most cases result in death. Since clinical treatments and immunomodulatory treatment methods in this area are insufficient, this issue should be discussed and investigated in more detail. In our current proceeding we are briefly discussing the cytokine storm.