Cancer and Wnt Pathway
Keywords:
Cancer, Wnt pathway, β –cateninAbstract
Today, mutations in genes, diet and lifestyle play a major role in causing cancer. Genetic factors are much lower on the list. Stress in particular can affect all our bodily functions, causing cancer cells to form and multiply uncontrollably. Stress and other factors negatively affect our immune system, making it unable to fight cancer stem cells. The Wnt/β-catenin pathway, which is an important pathway in cancer development, constitutes a key point for cancer treatment. In this proceeding review study, we will briefly discuss Wnt pathway in cancer.
References
Wnt Yolağı – Ankara Üniversitesi Açık Ders Malzemeleri
Pai, S. G., Carneiro, B. A., Mota, J. M., Costa, R., Leite, C. A., Barroso-Sousa, R., ... & Giles, F. J. (2017). Wnt/beta-catenin pathway: modulating anticancer immune response. Journal of hematology & oncology, 10, 1-12.
MacDonald, B. T., Tamai, K., & He, X. (2009). Wnt/β-catenin signaling: components, mechanisms, and diseases. Developmental cell, 17(1), 9-26.
Valenta, T., Hausmann, G., & Basler, K. (2012). The many faces and functions of β‐catenin. The EMBO journal, 31(12), 2714-2736.
Moon, R. T. (2005). Wnt/β-catenin pathway. Science's STKE, 2005(271), cm1-cm1.
Altınok, B. & Sunguroğlu, A. (2016). Wnt sinyal yolağı ve kanser . Ankara Sağlık Hizmetleri Dergisi , 15 (2) , 27-38 . https://doi.org/10.1501/Ashd_0000000118
Zhan, T., Rindtorff, N. & Boutros, M. Wnt signaling in cancer. Oncogene, 36, 1461–1473 (2017). https://doi.org/10.1038/onc.2016.304